Type: 
SSO Seminar
Date-Time: 
Wednesday, November 30, 2011 - 16:00 to 17:00
Location: 
Weniger 304
Event Speaker: 
David Altman, Willamette University
Local Contact: 
David McIntyre
Abstract: 

Generation of force is critical for many cellular processes. Central to these processes are motor proteins, proteins that use the cell’s chemical energy to create directed motion. Myosins are a family of motor proteins that generate motion along the filamentous protein actin using the energy of ATP hydrolysis. Single-molecule studies of myosin motors have led to a detailed understanding of their force-generating mechanism. However, an understanding of how a myosin functions also requires an understanding of how the motor is regulated by its cellular environment. In this talk, I will discuss single molecule optical trap studies as well as studies conducted in a cellular system that have helped us understand how a particular myosin class, myosin VI, is regulated in the cell. I will also describe preliminary results for studies of the regulated activities of two other myosin classes.