Type: 
Colloquium
Date-Time: 
Monday, October 2, 2017 - 16:00 to 17:00
Location: 
WNGR 116
Event Speaker: 
Ahmet Yildiz (Berkeley)
Local Contact: 
Weihong Qiu
Abstract: 

My laboratory has made significant contributions towards understanding the mechanism of cytoplasmic dynein, a dimeric motor responsible for minus-end directed motility along microtubules. We showed that, unlike kinesin and myosin motors, a dynein dimer moves without coordination between the monomers and follows a helical trajectory around microtubules. We presented a robust mechanistic model of dynein motility and force generation, and identified a unique ATPase site that repurposes dynein for different cellular functions. We also showed that the mammalian dynein-dynactin complex is a strong opponent of plus-end directed kinesins, and multiple dyneins team up more efficiently than kinesins during bidirectional cargo transport.

https://www.yildizlab.org/

 

 

Refreshments: 
Refreshments will be offered half an hour before the colloquium in Weniger 379